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Abstract #4351

Multi-contrast MRI of Myelination after Transplantation of Human Glial-Restricted Progenitor Cells in a Dysmyelinated Mouse Model

Antje Arnold 1,2 , Jiangyang Zhang 1,2 , Guanshu Liu 1,3 , Agatha Lyczek 1,2 , Miroslaw Janowski 1,4 , Jeff W.M. Bulte 1,2 , and Piotr Walczak 1,2

1 Dept. of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2 Cellular Imaging Section, Institute for Cell Engineering, Baltimore, Maryland, United States, 3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States, 4 NeuroRepair Department, Polish Academy of Sciences, Warsaw, Poland

Recent advances in regenerative medicine raise hope that the transplantation of human GRPs may be an effective approach to restore brain function in patients who suffer from myelin disorders. The detection of remyelination is still quite challenging with non-invasive MR imaging methods. The goal of our study was to improve the utility of non-invasive MR imaging for evaluation of myelination by human GRPs. Here we show that T2-w and quantitative magnetization transfer imaging revealed myelination after transplantation of hGRPs in a dysmyelinated mouse model. However, diffusion tensor imaging data did not show significant improvement compared to non-transplant controls.

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