Abstract #4355
Comparison of 3T Arterial Spin Labelling and Dynamic Contrast Enhanced MRI in Multiple sclerosis
Afaf S Elsarraj 1 , Paul S Morgan 2 , Cris S Constantinescu 3 , Dorothee P Auer 1 , and Robert A Dineen 1
1
Sir Peter Mansfield Imaging Centre, School
of Medicine, University of Nottingham, Nottingham,
United Kingdom,
2
Medical
Physics, Nottingham University Hospitals NHS Trust,
Nottingham, United Kingdom,
3
Clinical
Neurology Group, Division of Clinical Neuroscience,
University of Nottingham, Nottingham, United Kingdom
Haemodynamic changes have been reported in multiple
sclerosis (MS), using MRI techniques. However, the
extent to which the perfusion alterations detected are
comparable between these techniques is not well
understood. In this study we used arterial spin
labelling (ASL) and dynamic contrast enhance-MRI
(DCE-MRI) to test whether these two techniques are
comparable, by comparing cerebral blood flow (CBF)
values from basal ganglia in a cohort of MS patients and
matched healthy controls. Our findings suggest that
DCE-MRI is more sensitive than ASL in measuring
perfusion in multiple sclerosis.
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