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Abstract #4370

Relationship of Sodium concentration and T2 relaxation in Multiple Sclerosis

Patricia Alves Da Mota 1 , Marios C Yiannakas 1 , Ferran Prados 1,2 , Manuel Jorge Cardoso 1 , David Paling 3 , Frank Riemer 1 , Daniel Tozer 4 , Sbastien Ourselin 1 , David H Miller 1 , Xavier Golay 5 , Claudia AM Wheeler-Kingshott 1 , and Bhavana S Solanky 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Department of Medical Physics and Bioengineering Wolfson House, Translational Imaging Group CMIC, London, England, United Kingdom, 3 Department of Clinical Neurosciences, University of Sheffield, Sheffield, England, United Kingdom, 4 Department of Clinical Neurosciences, University of Cambridge, Cambridge, England, United Kingdom, 5 NMR Research Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, England, United Kingdom

In this study we look at the relationship between total sodium concentration (TSC) and T2 in multiple sclerosis, both of which are sensitive to demyelination. 1 H T2 increases are seen as the myelin water fraction reduces due to demyelination. A TSC increase is also expected as a result of demyelination, which causes an over-expression of sodium channels along the axon. However, increased TSC also occurs if extracellular space increases due to cell swelling or degradation. Here we look at the interaction between TSC and T2 in NAWM, NAGM, CSF, T1 and T2 lesions, in relapsing remitting and secondary progressive MS.

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