MR Perfusion of Human Brain Tumors Demonstrates Increased Blood Volume in Active Tumor before Static Contrast Enhancement or Permeability.
Ajay Nemani 1 , Mirko Vukelich 1 , Kristina Wakeman 2 , Tibor Valyi-Nagy 2 , and Keith Thulborn 1
Center for MR Research, University of
Illinois at Chicago, Chicago, IL, United States,
University of Illinois at Chicago, Chicago, IL, United
The spatial distribution of permeability (Ktrans) and
blood volume (Vb) as derived from dynamic contrast
enhanced (DCE) MRI and the extended Tofts model has been
investigated in human brain tumors to establish which
parameter is the earlier marker of tumor progression in
grade and for defining actively growing tumor margins.
Tumors were sampled with profiles extending across the
center and margins of the tumors. A histological study
of a resected tumor confirms growth of new vessels with
normal endothelial cells with increased Vb prior to
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