Abstract #4378
Tumour Response Assessment using volumetric DCE-CT and DCE-MRI in Metastatic Brain Cancer Patients
Catherine Coolens 1,2 , Brandon Driscoll 3 , Warren Foltz 4 , and Caroline Chung 4,5
1
Radiation Medicine Program, Princess
Margaret Cancer Centre and University Health Network,
Toronto, Ontario, Canada,
2
Radiation
Oncology and IBBME, University of Toronto, Toronto,
Ontario, Canada,
3
Radiation
Medicine Program, Princess Margaret Cancer Centre,
Ontario, Canada,
4
Princess
Margaret Cancer Centre, Ontario, Canada,
5
Radiation
Oncology, University of Toronto, Ontario, Canada
This study presents the evaluation of tumor perfusion
and permeability of metastatic brain cancers in response
to stereotactic radiation using both DCE MRI and
volumetric DCE CT at similar time points throughout
treatment. The aim was to evaluate the ability of
DCE-MRI and DCE-CT to detect changes in tumor vascular
physiology that predict for tumor response to SRS and to
compare DCE-MRI analysis against DCE-CT supported by a
common analysis framework to measure changes in vascular
parameters in brain metastases treated with SRS.
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