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Abstract #4383

Differentiation of Low-Grade and High-Grade Gliomas Using A Non-Gaussian Diffusion Imaging Model

Yi Sui 1,2 , Ying Xiong 1,3 , Karen Xie 4 , Frederick C. Damen 1 , Xiaohong Joe Zhou 1,5 , and Wenzhen Zhu 3

1 Center for MR Research, University of Illinois Hospital & Health Sciences System, Chicago, IL, United States, 2 Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3 Radiology, Tongji Hospital, Wuhan, Hubei, China, 4 Radiology, University of Illinois Hospital & Health Sciences System, Chicago, IL, United States, 5 Departments of Radiology, Neurosurgery and Bioengineering, University of Illinois Hospital & Health Sciences System, Chicago, IL, United States

Fractional order calculus (FROC) diffusion model can provide additional parameters to characterizing not only the average diffusion speed, but also the complexity of tissue structures. Previous studies have shown promising results of using the FROC model to differentiate pediatric brain tumors. In this study, we have applied the FROC model to a group of adult gliomas patients and demonstrated its capability of improving the MR-based diagnostic accuracy for differentiating low-grade from high-grade gliomas.

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