Abstract #4386
Towards imaging tumor cellularity: diffusion basis spectrum imaging (DBSI) and amide proton transfer (APT)
Chien-Yuan Eddy Lin 1,2 , Bing Wu 2 , Hung-Wen Kao 3,4 , Peng Sun 5 , Yong Wang 5 , and Sheng-Kwei Song 5
1
GE Healthcare, Taipei, Taiwan,
2
GE
Healthcare China, Beijing, China,
3
Tri-Service
General Hospital, National Defense Medical Center,
Taipei, Taiwan,
4
Department of Biomedical
Imaging and Radiological Sciences, National Yang-Ming
University, Taipei, Taiwan,
5
Department
of Radiology, Washington University School of Medicine,
St. Louis, MO, United States
Tumor cellularity is an important indicator of
aggressiveness and the efficiency of chemotherapy. Amide
proton transfer (APT) imaging detects the proton
exchange between bulk water and the amide protons in
endogenous mobile proteins and peptides. Previous
studies demonstrated that APT grading of diffuse gliomas
might reflect tumor cellularity. Recently, a newly
developed diffusion basis spectrum imaging (DBSI) models
tissue water diffusion as a linear combination of
anisotropic and isotropic diffusion tensors4, allowing
the quantification of restricted and non-restricted
isotropic diffusion tensor components reflecting the
extent of cellularity and edema respectively. The aim of
this study was to assess changes in APT and DBSI metrics
in conventional MRI identified brain tumors.
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