Abstract #4396
Intracellular Sodium (23Na) MRI for Assessment of Response to Cancer Therapies on Brain Tumor Patients
Yongxian Qian 1 , Charles M. Laymon 2 , Matthew J. Oborski 3 , Jan Drappatz 4 , Frank S. Lieberman 4 , and James M. Mountz 2
1
Qian's Lab for MRI, General Labs Cloud LLC,
Pittsburgh, PA, United States,
2
Radiology,
University of Pittsburgh, Pittsburgh, PA, United States,
3
Bioengineering,
University of Pittsburgh, Pittsburgh, PA, United States,
4
Neurology
and Medicine, University of Pittsburgh, Pittsburgh, PA,
United States
This work demonstrates the potential of intracellular
sodium concentration as an endogenous imaging biomarker
for noninvasive assessment of early response of brain
tumors to therapies with radiation and chemotherapy in
clinical setting. Eight patients with glioblastoma
multiforme (GBM) were studied with intracellular sodium
MRI on a clinical 3T scanner at three time points:
baseline, 1- and 2-month follow-ups. Quantified total
sodium concentration and bound (mostly intracellular)
sodium concentration were used to reflect the growth or
death of cancer cells in response to therapies.
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