Abstract #4408
Preliminary Multimodal MR Imaging Evaluation in Blast-induced Traumatic Brain Injury Rat Model
Xiao Wang 1 , Xiao-hong Zhu 1 , Afshin Divani 2 , Yi Zhang 1 , and Wei Chen 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota Medical
School, Minneapolis, Minnesota, United States,
2
Department
of Neurology, University of Minnesota, Minnesota, United
States
Blast-induced traumatic brain injury (bTBI) is of
particular relevance to the military battles and urban
terrorist attacks and has increasingly gained public
attention. Proper preclinical bTBI models and
noninvasive neuroimaging tools are crucial for early
diagnosis, neuropathology progression monitor and
treatment efficacy evaluation. We performed multiple MRI
measures in a new bTBI rat model and found a highly
synchronized and widely distributed rs-fMRI connectivity
across almost the entire brain in some of the bTBI rats.
This rs-fMRI characteristic is not sensitive to the
presence of macroscopic lesion, baseline cerebral blood
flow (CBF) and impaired cerebrovascular reactivity, but
is persistent in the same rat for a long period of time.
The abnormal connectivity pattern of lacking functional
specificity might be related to the diminished brain
functional segregation, disrupted neural excitation
and/or inhibition and compensatory neuronal processes
caused by the injury. The overall results reveal that
the rs-fMRI can serve as a sensitive neuroimaging
biomarker for noninvasively studying the underlying
neuropathology mechanisms of the bTBI using a rat model,
which should have a constructive impact for clinical
translation in human TBI patients.
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