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Abstract #4416

White Matter Abnormalities in Acute Mild Traumatic Brain Injury: A Diffusion Kurtosis MRI Study

Sohae Chung 1,2 , Els Fieremans 1,2 , Jelle Veraart 1,2 , Dmitry S. Novikov 1,2 , Jacqueline Smith 1,2 , Steven R. Flanagan 3 , and Yvonne W. Lui 1,2

1 Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, 2 Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 3 Department of Rehabilitation Medicine, New York University Langone Medical Center, New York, NY, United States

Mild traumatic brain injury (mTBI) is a growing public health problem; however, overall sensitivity to white matter (WM) injury and understanding of the underlying pathophysiology is limited. Here, we investigate WM abnormalities in mTBI by using WM diffusion metrics, as derived from DKI with a two-compartment model. Using TBSS and ROI analyses, we demonstrate that there are several metrics that are sensitive to injury after mTBI, suggesting that increased restrictions along the axons, both inside and outside, such as possibly axonal beading, could occur acutely after injury. This provides unique insight into the underlying mechanisms of WM alterations after mTBI.

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