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Abstract #4426

Cervical myelopathy patient follow-up after decompressive surgery using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT): preliminary application and results

Manuel Taso 1,2 , Olivier M. Girard 3,4 , Guillaume Duhamel 3,4 , Thorsten Feiweier 5 , Pierre-Jean Arnoux 2 , Maxime Guye 3,4 , Jean-Philippe Ranjeva 3,4 , Kathia Chaumoitre 6 , Pierre-Hugues Roche 7 , and Virginie Callot 3,4

1 CRMBM-CEMEREM UMR 7339, Aix-Marseille Universit, CNRS, Marseille, France, 2 LBA UMR T 24, Aix-Marseille Universit, IFSTTAR, Marseille, France, 3 CRMBM UMR 7339, Aix-Marseille Universit, CNRS, Marseille, France, 4 CEMEREM, Pole d'imagerie mdicale, Hopital la Timone, AP-HM, Marseille, France, 5 Siemens AG, Healthcare, Erlangen, Germany, 6 Service de radiologie, Hopital Nord, Pole d'imagerie mdicale, AP-HM, Marseille, France, 7 Service de Neurochirurgie,Trauma Center, Hopital Nord, AP-HM, Marseille, France

Cervical myelopathy diagnosis and management in clinical practice still lacks of objective markers of potential surgery outcome. Therefore, we applied a multimodal MRI protocol, combining DTI (known to be more predictive of surgical outcome than the sole presence of T2 hyperintensity) and inhomogeneous magnetization transfer (ihMT, myelin-specific technique) to 2 patients before and 3 months after decompressive surgery. We observed both metrics evolution after surgery and neurological function evolution to see whether this multimodal protocol could help in understanding the evolutive pattern of the disease after surgery. Longitudinal follow-up until 1year post-surgery will help in answering the raised question.

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