Abstract #4432
CEST of the Cervical Spinal Cord at 7 Tesla
Adrienne Dula 1 , Siddharama Pawate 1 , Lindsey M Dethrage 1 , Benjamin N Conrad 1 , Robert L Barry 1 , and Seth A Smith 1
1
Vanderbilt University, Nashville, Tennessee,
United States
Optimal CEST saturation parameters found via simulation
were implemented for CEST MRI in ten healthy controls
and ten MS patients and results were examined using
traditional asymmetry analysis and Lorentzian fit
method. Distinct spectral features for all tissue types
studied were found both up- and down-field from the
water resonance. The z-spectra in healthy subjects had
the expected z-spectra shape with CEST effects apparent
from 2.0 ppm 4.5 ppm while the z-spectra from MS
patients demonstrated deviations from this expected,
normal shape indicating this methods sensitivity to
known pathology as well as those tissues appearing
normal on conventional MRI.
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