Abstract #4467
Intralipid Reduces Post-MI Ventricular Remodeling and Heart Failure after Ischemic Injury
Yijen Lin Wu 1,2 , Fang-Cheng Yeh 3 , and Chien Ho 4
1
Developmental Biology, University of
Pittsburgh, Pittsburgh, PA, United States,
2
Rangos
Research Center Imaging Core, Children's Hospital of
Pittsburgh of UPMC, Pittsburgh, PA, United States,
3
Psychology,
Carnegie Mellon University, Pittsburgh, PA, United
States,
4
Biological
Sciences, Carnegie Mellon University, Pittsburgh, PA,
United States
Coronary heart disease is the leading cause of death in
US. Timely re-circulation has greatly decreased 30-day
in-hospital death, and increased survival rate during
the acute phase of myocardium infarction (MI). However,
even with successful blood-flow restoration, ischemia
reperfusion injury (IRI) can result in greater tissue
damage and adverse remodeling. The rate of developing
post-MI heart failure increases as the acute mortality
decreases. Long-term post-MI ventricular remodeling and
the consequent potential heart failure remains a
challenge. We report here that Intralipid can preserve
heart function after IRI can reduce long-term post-MI
ventricular remodeling.
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