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Abstract #4492

Heart-Rate Independent, Whole-Heart, Free-Breathing, Quantitative Myocardial BOLD MRI at 3T with Simultaneous 13N-Ammonia PET Validation in Canines

Hsin-Jung Yang 1 , Damini Dey 2 , Jane Sykes 3 , John Butler 3 , Avinash Kali 2 , Ivan Cokic 2 , Behzad Sharif 2 , Sotirios Tsaftaris 4 , Debiao Li 2 , Piotr Slomka 2 , Frank Prato 3 , and Rohan Dharmakumar 2

1 Cedars Sinai Medical Center, Los angeles, CA, United States, 2 Cedars Sinai Medical Center, CA, United States, 3 Lawson Health Research Institute, ON, Canada, 4 IMT Lucca Institute, Lucca, Italy

Myocardial BOLD MRI is an emerging non-contrast approach for assessing ischemic heart disease. Current myocardial BOLD methods are limited by poor spatial coverage, heart-rate dependency and image artifacts (e.g. coil bias, B1 and B0 inhomogeneities). To overcome these limitations, we developed a heart-rate independent, fast, free breathing 3D T2 mapping technique at 3T that utilizes near perfect imaging efficiency. This quantitative BOLD approach, which can be performed within 3 minutes, permits full LV coverage during pharmacological stress. In this study, we tested our approach in a canine model and validated our findings with simultaneously acquired 13N-ammonia PET perfusion data in a clinical PET-MR system.

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