The Effects of Injection Rate on Vascular Signal Intensity Profile in a Porcine Model using Four Gadolinium Contrast Agents: Comparison Between Observation and Prediction Based on Measured Blood Relaxivity Values
Jeffrey H Maki 1 , Guenther Schneider 2 , Alexander Massmann 2 , Matthias Leist 2 , Diane Wagner-Jochem 2 , and Gregory J Wilson 1
Radiology, University of Washington,
Seattle, WA, United States,
University Hosptial of Saarland, Homburg, Germany
Eight juvenile swine were imaged with high temporal
resolution (1.7 s) CE-MRA 3x each during the bolus
passage of one of four Gd agents at 1,2,3 ml/sec (2
animals/agent, all single dose, 24 total injections).
Simultaneous aortic blood sampling was performed (every
2 s) to measure actual Gd concentration. Ex vivo
arterial blood was doped with each contrast agent to
determine R1 and R2* vs. [Gd]. Predicted and actual
signal intensity (SI) vs. time as well as bolus duration
were compared, demonstrating a relatively flat SI
response vs. injection rate, validating the benefit of
slower Gd injections for CE-MRA.
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