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Abstract #0005

Diffusion Kurtosis at varying diffusion times in the normal and injured mouse brains

Dan Wu1, Frances J Northington2, and Jiangyang Zhang1,3

1Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 2Pediatrics, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 3Radiology, New York University School of Medicine, New Yourk, NY, United States

To investigate the diffusion time dependence of diffusion kurtosis, we measured kurtosis at varying diffusion times using pulsed and oscillating gradients. The results showed reduced kurtosis as diffusion time decreased from 25 ms to 2.5 ms in the normal adult mouse brains, and the differences were higher in the gray matter than the white matter regions. Results from neonatal mice with severe hypoxic-ischemic injury showed that both kurtosis measurements at short and long diffusion times elevated in the edema region, and the changes were heterogeneous in the hippocampus, which may be correlated with long-term outcome.

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