Abstract #0020

Remodeling of energy metabolism revealed by 31P magnetization transfer in a transgenic rat model of Huntington’s disease

Brice Tiret^1,2, Maria-Angeles Carrillo-de Sauvage^1,2, Huu Phuc Nguyen^3,4, Nicole El Massioui^5,6, Valérie Doyère^5,6, Vincent Lebon^1,2, Emmanuel Brouillet^1,2, and Julien Valette^1,2

¹CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, ²CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France, ³Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany, ⁴Centre for Rare Diseases, University of Tuebingen, Tuebingen, Germany, ⁵Paris-Saclay Institute of Neuroscience, Université Paris-Sud, UMR 9197, Orsay, France, ⁶Centre National de la Recherche Scientifique, Orsay, France

Localized ³¹P MRS with progressive magnetization transfer (MT) is performed in the BACHD transgenic rat model of Huntington’s disease to assess energy metabolism. Localized measurements of the ATP formation rate through creatine kinase and oxidative phosphorylation (ATPsynthase) are performed in the rat brain for the first time. Results show that ATPsynthase rate is reduced by a factor 2, which is partly compensated by higher cerebral concentrations of phosphocreatine to generate ATP via creatine kinase.

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