Abstract #0054

Cerebral venous oxygenation as a potential marker to differentiate normal aging from neurodegeneration

Zixuan Lin¹, Marilyn Albert², Peiying Liu³, Anja Soldan², Abhay Moghekar³, Shin-Lei Peng⁴, Michael Miller¹, Peter van Zijl³, and Hanzhang Lu³

¹Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ²Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Radiology, China Medical University, Taichung, Taiwan

Decreased cerebral venous oxygenation (Yv) has been considered as a compensation for aging which is diminished in neurodegeneration. We substantiated this hypothesis by examining the relationship between Yv and several Alzheimer-specific hallmarks on 65 normal elderly subjects. We demonstrated that Yv is higher in ApoE4 carriers who have increased risks of AD and that higher Yv is associated with poorer cognitive performance, indicating that assessment of Yv with non-invasive MRI methods may present a potential simple opportunity to identify the transition point from normal to pathological aging.

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