Adrian Tsang1,2,3, Catherine Lebel1,4, Signe Bray1,4, Brad Goodyear1,2,3, Roberto C. Sotero1, Cheryl McCreary1,3, and Richard Frayne1,2,3
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, Calgary, AB, Canada, 3Seaman Family MR Research Centre, Calgary, AB, Canada, 4Child and Adolescent Imaging Research Program, Alberta Children's Hospital Research Institute, Calgary, AB, Canada
This study investigates how both structural and functional
connectivity (SC and FC) changes in the adult lifespan as well as to explore
the relationship between measures that are commonly used for SC and FC in the
context of normal aging. A multi-modal analysis using DTI and resting-state
fMRI data was performed from 183 healthy participants aged 18 – 87 years. We
found that fractional anisotropy (FA) and FC showed similar rate of change and
correlation strengths with age in the 7 resting-state networks explored.
However none of the SC measures showed significant correlations with FC
measure.
