Abstract #0089

The value of MRI in Traumatic Brain Injury: experiences in the Collaborative European NeuroTrauma Effectiveness Research in TBI study

Pim Pullens¹, Andrew IR Maas², David Menon³, Wim van Hecke⁴, Jan Verheyden⁴, Lene Claes⁴, Paul M Parizel¹, and On behalf of CENTER-TBI participants and investigators⁵

¹Radiology, Antwerp University Hospital & University of Antwerp, Antwerp, Belgium, ²Neurosurgery, Antwerp University Hospital & University of Antwerp, Antwerp, Belgium, ³Anaesthesia, University of Cambridge, Cambridge, United Kingdom, ⁴icometrix NV, Leuven, Belgium, ⁵University Hospital Antwerp, Antwerp, Belgium

Traumatic Brain Injury (TBI) is regarded as “the most complex disease in our most complex organ”. Clinical outcome is unpredictable, especially in repetitive mild TBI, in terms of behavior, cognition, emotion and associated long-term effects such as dementia. The Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study is a pan-European prospective longitudinal observational study aiming to improve care for TBI patients. One of the key goals is to improve the quality of imaging-derived data by the application of a clinical standardized MR imaging protocol including structural, SWI, DTI and rs-fMRI, across up to 25 clinical sites in a large, heterogeneous sample of TBI patients. Harmonization of these protocols has been a challenging task. As data collection is underway, 265 datasets have been inspected for quality. Data quality is variable across sites and scanners. In order for such large-scale observational studies to be really effective, sequence harmonization and standardization is of key importance, but lacking at the moment.

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