Though, ketamine possess
rapid antidepressant properties, its use is limited due to addictive and
psychotomimetic properties. In the current study, we have evaluated the
antidepressant activity of lanicemine in CUMS model of depression by 1H-[13C]-NMR
spectroscopy together with infusion of [1,6-13C2]glucose. Exposure of lanicemine restored behavioral
phenotype and activity of excitatory and inhibitory neurons in depression.