Modulations of cerebral TCA cycle activity studied by hyperpolarized Acetate 13C MRS
Elise Vinckenbosch1, Mor Mishkovsky1, Arnaud Comment2, and Rolf Gruetter1,3
1Laboratory of functional and metabolic imaging, EPFL, Lausanne, Switzerland, 2Institute of Physics of Biological Systems, EPFL, Lausanne, Switzerland, 3Department of Radiology, University of Lausanne and Geneva, Lausanne, Switzerland
Hyperpolarized [1-13C] acetate enables for in vivo detection
of 2-oxoglutarate, a tricarboxylic acid (TCA) cycle intermediate, in intact
brain at high field. The aim of this study is to examine saturation substrate
dose conditions and to compare it with a partially inhibited TCA cycle model. We conclude that
2-oxoglutarate production rate can be calculated as a function of varying
substrate concentrations and is affected as well as the cerebral acetate kinetics by TCA cycle activity modulations.
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