Abstract #0131

Multimodality functional imaging in radiation therapy during treatment: relationship between DW-MRI and 18F FDG PET in head and neck squamous cell carcinoma

David Aramburu Nuñez^1,2, Antonio Lopez Medina³, Moises Mera Iglesias⁴, Francisco Salvador Gomez⁵, Vaios Hatzoglou⁶, Ramesh Paudyal¹, Alfonso Calzado², Joseph O Deasy¹, Amita Shukla-Dave⁷, and Victor M Muñoz⁸

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ²Department of Radiology, Complutense University, Madrid, Spain, ³Medical Physics & Radiological Protection, Galaria - Hospital do Meixoeiro – Complexo Hospitalario Universitario de Vigo, Vigo, Spain, ⁴Medical Physics, Oncoserv, Santiago de los Caballeros, Dominican Republic, ⁵Medical Physics and Radiological Protection, Galaria - Hospital do Meixoeiro – Complexo Hospitalario Universitario de Vigo, Vigo, Spain, ⁶Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ⁷Medical Physics & Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ⁸Radiation Oncology, Galaria - Hospital do Meixoeiro – Complexo Hospitalario Universitario de Vigo, Vigo, Spain

Biologically guided radiotherapy needs an understanding of how different functional imaging techniques interact and link together. DW-MRI and 18F FDG-PET techniques were used in this study for achieving this objective. 5 HPV-, HNSCC patients underwent 20 DW-MRI and 10 18F-FDG-PET/CT scans before and during radiation therapy. ADC maps derived from DW-MRI and SUV values from 18F-FDG were used for evaluating tumor response. The initial evaluation of the preliminary results suggests that in these solid tumors cellularity is inversely proportional to the glucose metabolic uptake. The survival status and functional metrics show different trends for NED, AWD and DOD.

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