Abstract #0134

Assessment of early treatment response by IVIM DW-MRI and DCE-MRI in patients with brain metastases treated with stereotactic radiosurgery.

David Aramburu Nuñez^1,2, Kathryn Beal³, Vaios Hatzoglou⁴, Andrei Holodny⁴, Ramesh Paudyal¹, Yonggang Lu⁵, Joseph O Deasy¹, and Amita Shukla-Dave⁶

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ²Department of Radiology, Complutense University, Madrid, Spain, ³Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ⁴Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ⁵Radiation Oncology, Washington University, St. Louis, MO, United States, ⁶Medical Physics & Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

In clinical settings it is essential to accurately assess, whether or not a brain metastasis has been successfully treated or whether the metastasis require additional treatment. This is the first study that evaluated brain metastases with IVIM DW-MRI and DCE-MRI data both pre- and post- stereotactic radiosurgery (SRS). The preliminary results are promising as it will inform the treating physicians at an early time point about which patients will benefit from SRS (or not). The survival status and functional metrics show different trends for both AWD and DOD that need to be validated in larger patient population.

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