Abstract #0144

Elevated Hemoglobin A1c(HbA1c) Is Independently Associated with Large Lipid-Rich Necrotic Cores in Hypertensive Patients with Symptomatic Carotid Atherosclerosis: A 3.0T MRI Study

Huilin Zhao¹, Beibei Sun¹, Xiaosheng Liu¹, Xihai Zhao², Yongming Dai³, Chun Yuan⁴, and Jianrong Xu¹

¹Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, People's Republic of, ²Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China, People's Republic of, ³Philips Healthcare, Shanghai, China, People's Republic of, ⁴Radiology, University of Washington, Seattle, WA, United States

Further understanding of the association of hemoglobin A_1c(HbA_1c) levels with symptomatic carotid plaque characteristics will be helpful for stroke risk stratification and treatment strategy modification. This study sought to investigate the associations of HbA_1c levels with MR-identified carotid plaque characteristics in hypertensive patients with acute stroke. Our key findings are that elevated HbA_1c was associated with carotid plaque presence, higher HbA_1c level tended to exhibit an increased plaque burden and larger lipid-rich necrotic core, independent of other cardiovascular risk factors. Our findings indicate that elevated HbA_1c may contribute to the development of advanced carotid plaques in stroke patients with hypertension.

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