Abstract #0150

Brain phospholipid and energy metabolism in mild Alzheimer’s disease and healthy aging: a 31P Magnetic Resonance Spectroscopy study

Anne Rijpma^1,2, Marinette van der Graaf^3,4, Olga Meulenbroek^1,2, Marcel Olde Rikkert^1,2, and Arend Heerschap³

¹Geriatric Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, Netherlands, ³Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ⁴Paediatrics, Radboud university medical center, Nijmegen, Netherlands

In this study we assessed phospholipid and energy metabolism in patients with mild Alzheimer’s disease and healthy age-matched control subjects by 3D ³¹P MRS imaging. Four brain regions were investigated: left and right hippocampus, anterior cingulate cortex, and retrosplenial cortex. Disease specific differences as well as differences between brain regions were found.

This abstract and the presentation materials are available to members only; a login is required.

Join Here