Abstract #0178

Magnetic resonance elastography characterization of skeletal muscle stiffness changes resulting from pressure ulcers

Jules Laurent Nelissen^1,2, Willeke Traa³, Larry de Graaf¹, Kevin Moerman⁴, Cees Oomens³, Aart Nederveen⁵, Ralph Sinkus⁶, Klaas Nicolay¹, and Gustav Strijkers²

¹Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, ²Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands, ³Biomechanics of Soft Tissues, Eindhoven University of Technology, Eindhoven, Netherlands, ⁴MIT media lab, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Radiology, Academic Medical Center, Amsterdam, Netherlands, ⁶Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom

We have investigated the feasibility of using Magnetic Resonance Elastography (MRE) to quantify muscle-tissue mechanical properties and changes therein related to the development of deep tissue injury type of pressure ulcers. MRE measurements were performed before and after damage-inducing indentation of the tibialis-anterior muscle of Sprague Dawley rats. Current study demonstrates that changes in muscle-tissue mechanical properties associated with deep tissue injury can be quantified by MRE. We expect that better knowledge of changes in soft tissue mechanical properties due to damage, measured with MRE, will provide new insights in the aetiology of deep tissue injury and other muscle pathologies.

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