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Abstract #0219

Mapping resting state networks in epilepsy with Arterial Spin Labeling connectivity analysis

Ilaria Boscolo Galazzo1,2, Silvia Francesca Storti3, Anna Barnes1, Enrico De Vita4, Francesca Benedetta Pizzini2, John Duncan5, Ashley Groves1, Gloria Menegaz3, and Francesco Fraioli1

1Institute of Nuclear Medicine, University College London, London, United Kingdom, 2Department of Neuroradiology, University Hospital Verona, Verona, Italy, 3Department of Computer Science, University of Verona, Verona, Italy, 4Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 5Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom

In this study, we propose the assessment of resting-state brain networks (RSNs) using Arterial Spin Labeling perfusion MRI as an alternative to the gold-standard sequence represented by the Blood-oxygenation-level-dependent (BOLD) contrast. RSNs have been derived by means of independent component analysis (ICA) and spatially compared to literature networks. In addition, functional connectivity changes in epileptic patients have been quantified in comparison to healthy controls. The results demonstrated ASL suitability in identifying RSNs, with a strong agreement with BOLD, and in detecting functional alterations in pathological conditions.

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