Assessment of brain cognitive functions in patients with vitamin B12 deficiency using resting state functional MRI
Lalit Gupta1, Rakesh K Gupta2, Pradeep K Gupta2, Hardeep Singh Malhotra3, Indrajit Saha4, and Ravindra K Garg3
1Philips India Ltd., Bangalore, India, 2Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India, 3Department of Neurology, King George Medical University, Lucknow, India, 4Philips India Ltd., Gurgaon, India
The alterations in the
brain cognitive functions due to vitamin B12 deficiency and reversibility of
these alterations following therapy was studied using resting state fMRI. Regional
Homogeneity (ReHo) was used to assess functional changes in patients with vitamin
B12 deficiency. ReHo was significantly lower in patients than controls in the
entire cerebrum and in the brain networks associated with cognition control
i.e. default mode, cingulo-opercular and fronto-parietal network. We conclude that the brain
networks associated with cognition control, in particular pre-frontal regions,
are altered in patients with vitamin B12 deficiency that partially recovered
following six weeks of replacement therapy.
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