Caroline Guglielmetti1,2, Chloe Najac1, Annemie Van der Linden2, Sabrina M Ronen1, and Myriam M Chaumeil1
study demonstrates that 13C MRS of hyperpolarized pyruvate can be
used to detect increased lactate production from pro-inflammatory macrophages,
mechanism mediated by pyruvate dehydrogenase kinase-1 upregulation and pyruvate
dehydrogenase inhibition, in a preclinical model of multiple sclerosis, hence
providing a novel tool for in-vivo
detection of neuroinflammation.