Abstract #0246

In vivo 7T Quantitative Susceptibility Mapping of Cortical Lesions in Multiple Sclerosis

Wei Bian¹, Eric Tranvinh¹, Thomas Tourdias², May Han³, Tian Liu⁴, Yi Wang⁴, Brian Rutt¹, and Michael Zeineh¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Service de NeuroImagerie Diagnostique et Thérapeutique, CHU de Bordeaux, Bordeaux, France, ³Department of Neurology, Stanford University, Stanford, CA, United States, ⁴Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States

Magnetic susceptibility measured with quantitative susceptibility mapping (QSM) has been proposed as a biomarker for inflammation in multiple sclerosis (MS) white matter (WM) lesions. However, a detailed in vivo characterization of cortical lesions has not been performed. In this study, the susceptibility in both cortical and WM lesions relative to adjacent normal-appearing parenchyma was measured and compared for 14 MS patients using QSM at 7T. Our results showed that relative susceptibility was negative for cortical lesions but positive for WM lesions. The opposite pattern of relative susceptibility suggests that iron loss dominates the susceptibility contrast in cortical lesions.

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