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Abstract #0258

Quantitative Muscle Perfusion with DCE-MRI Shows Distinct Load-Dependent Exercise-Stimulated Muscle Perfusion Patterns

Jeff L. Zhang1, Christopher Hanrahan1, Christopher C. Conlin1, Corey Hart2, Gwenael Layec2, Kristi Carlston1, Daniel Kim1, Michelle Mueller3, and Vivian S. Lee1

1Radiology, University of Utah, Salt Lake City, UT, United States, 2Internal Medicine, University of Utah, Salt Lake City, UT, United States, 3Vascular surgery, University of Utah, Salt Lake City, UT, United States

Noninvasive mapping of calf muscle perfusion with high spatial resolution has potential for assessing the severity of peripheral artery disease (PAD) and studying associated capillary density abnormality. We tested our novel DCE-MRI method to measure calf muscle hyperemia stimulated by plantar flexion at three different workloads. Increases in exercise load caused increased total perfusion in gastrocnemius, with a heterogeneous pattern at medium load and homogeneous at higher load. Perfusion in soleus did not increase until very heavy load of 16 lbs. DCE-MRI provides high spatial resolution measurement of post-exercise muscle perfusion.

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