Abstract #0266

Measurement of proteoglycan concentration in intervertebral discs assessed by 1HMRS at 1.5T

Lisa Maria Harris^1,2, Ella Hodder^2,3, Mara Cercignani², Jan Bush², Derek Convill³, Paul Colley¹, and Nicholas Dowell²

¹Radiological Sciences, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom, ²Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, ³Computing, Engineering and Mathematics, University of Brighton, Brighton, United Kingdom

An assessment was made to determine whether proteoglycan concentration could accurately be quantified at 1.5T using 1HMRS in a group of 13 healthy volunteers. A peak from the N-acetyl resonance associated with proteoglycan was seen in all thirteen spectra, and reliably measured (308.8±59.9). This compares favourably with studies performed at higher field strengths, thus showing that is it possible even at 1.5T to measure proteoglycans in intervertebral discs.

This abstract and the presentation materials are available to members only; a login is required.

Join Here