Abstract #0278

Developmental processes on the neonatal brain revealed by white matter tract integrity metrics derived from diffusion kurtosis imaging

Xianjun Li^1,2, Jie Gao¹, Yumiao Zhang¹, Yanyan Li¹, Huan Li¹, Mingxi Wan², and Jian Yang^1,2

¹Radiology Department of the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China, People's Republic of, ²Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China, People's Republic of

To distinguish axon-related and myelin-related developmental processes, we tried to find a strategy for assessing white matter developmental processes by using white matter tract integrity (WMTI) metrics derived from diffusion kurtosis imaging (DKI). The method was used on 41 neonates. The proposed strategy provided more processes than conventional diffusion tensor imaging (DTI) method. Five change patterns were found for WMTI metrics, while 2 patterns for DTI metrics. WMTI metrics derived from DKI could provide more detailed developmental processes on neonatal white matter.

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