Abstract #0283

Transcranial MRI-Guided High-Intensity Focused Ultrasound for Treatment of  Essential Tremor: Initial Clinical Experience and Correlation of Clinical Outcome with Lesion Size, Localization, and Dose

Christian Federau¹, Maged Goubran¹, Jason Su¹, Jaimie Henderson¹, Veronika Santini¹, Casey Harrison Halpern¹, Brian Rutt¹, Kim Butts Pauly¹, and Pejman Ghanouni¹

¹Stanford University, Stanford, CA, United States

Transcranial MR-guided high-intensity focused ultrasound ablation of the ventral division of the ventral lateral posterior thalamic nucleus (VLpv) is a promising, minimally invasive treatment method for essential tremor. We report our initial clinical experience in 11 patients, and correlate clinical outcome with lesion size, location, and thermal dose during treatment. We found a correlation between clinical outcome at 1 year follow-up and lesion size (r = 0.73), as well as thermal dose in the VLpv (r = 0.65).

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Transcranial MRI-Guided High-Intensity Focused Ultrasound for Treatment of Essential Tremor: Initial Clinical Experience and Correlation of Clinical Outcome with Lesion Size, Localization, and Dose

Transcranial MRI-Guided High-Intensity Focused Ultrasound for Treatment of  Essential Tremor: Initial Clinical Experience and Correlation of Clinical Outcome with Lesion Size, Localization, and Dose