Shanshan Jiang1, Xianlong Wang1, Hao Yu1, Jiandong Xi1, Jingwen Wu1, Lisong Liang1, Shilong Lu1, Tianyu Zou1, Jinyuan Zhou2, and Zhibo Wen1
1Department of Radiology, Southern Medical University Zhujiang Hospital, Guangzhou, China, People's Republic of, 2Department of Radiology, Johns Hopkins University, Baltimore, MD, United States
The correlation between endogenous protein-based
APT-weighted (APTw) imaging and gene expression in glioblastoma (GBM) was
investigated. 16 patients with newly
diagnosed GBM were studied.
APTw/FLAIR hyperintensity area ratio (AFR), and APTw hyperintensity/gadolinium
contrast-enhanced T1w enhancement area ratio (ATR) were calculated.
Interoperative paired tumor and adjacent normal tissues were sampled for
genomic analysis. BRCA1 and CDK4 were
in the high AFR group
(adjusted P= 0.000953 and 0.025187), and SLAMF9 and MIA
were significantly downregulated in
the high ATR
group (adjusted P= 1.08E-11 and 0.00997). APT imaging has great potential for unveiling
some special genomic changes in GBM.