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Abstract #0293

Relationship of invivo MR parameters to molecular characteristics of non-enhancing lower-grade gliomas

Tracy L Luks1, Tracy Richmond McKnight1, Aurelia Williams1, Evan Neill1, Khadjia Lobo1, Anders Persson2, Arie Perry3, Joanna Phillips3, Annette Molinaro4, Susan Chang4, and Sarah J Nelson1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Neurology, University of California San Francisco, San Francisco, CA, United States, 3Pathology, University of California San Francisco, San Francisco, CA, United States, 4Neurosurgery, University of California San Francisco, San Francisco, CA, United States

Invivo MR anatomy, diffusion, perfusion, and spectroscopy profiles from non-enhancing grade 2 and grade 3 gliomas were examined by histologic and molecular characteristics associated with clinical outcome. Patients underwent a pre-surgical 3T MR exam including IRSPGR, FSE, FLAIR, DWI, MRSI and DSC. For surgical biopsies, histological sub-type, grade, cleaved caspase-3, MIB-1, Ki67, IDH1R132H, ATRX, p53, and co-deletion of 1p19q were determined. Overall, molecular characteristics associated with worse clinical outcome were associated with higher ADC and lower FA, lower nCBV and nPH, and higher Recov, and higher nLAC.

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