Abstract #0312

Functional MRI reveals striatal–thalamic connectivity in cognitive neural behavior altered by central thalamic deep brain stimulation

Hsin-Yi Lai¹, Hui-Ching Lin^2,3, Yu-Chun Lo⁴, Lun-De Liao^5,6, Wei-Che Wei⁷, and You-Yin Chen⁷

¹Interdisciplinary Institute of Neuroscience and Technology (ZIINT), Zhejiang University, Hangzhou City, China, People's Republic of, ²Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan, ³Brain Research Center, National Yang Ming University, Taipei, Taiwan, ⁴Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan, ⁵Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County, Taiwan, ⁶Singapore Institute for Neurotechnology, National University of Singapore, Singapore, Singapore, ⁷Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan

This study demonstrates neuronal striatal–thalamic connectivity modulated by direct stimulating the central thalamus in rats. Our results indicate that the CT-DBS modulate the neuronal activity in bilateral anterior cingulate cortex, caudate-putamen and somatosensory cortex and increases in functional connectivity between the striatum and parafascicular thalamic nucleus, hippocampus and primary motor cortex to shorten the cognitive related behavior task. CT-DBS fMRI has potential to explore functional connectivity in the brain and monitor functional plasticity changes in a specific neuroanatomical pathway in vivo.

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