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Abstract #0319

Pressure Gradient Measurement in the Coronary Artery Using Phase Contrast (PC)-MRI: Initial Patient Results Towards Noninvasive Quantification of Fractional Flow Reserve

Zixin Deng1,2, Sangeun Lee3, Zhaoyang Fan1, Christopher Nguyen1, Iksung Cho3, Qi Yang1, Xiaoming Bi4, Byoung-Wook Choi5, Jung-Sun Kim3, Daniel Berman1, Hyuk-Jae Chang3, and Debiao Li1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Cardiology, Severance Hospital, Yonsei Univeristy College of Medicine, Seoul, Korea, Republic of, 4R&D, Siemens Healthcare, Los Angeles, CA, United States, 5Radiology, Severance Hospital, Yonsei Univeristy College of Medicine, Seoul, Korea, Republic of

Fractional flow reserve is an invasive diagnostic tool to evaluate the functional significance of a coronary stenosis by quantifyin­g the pressure gradient (ΔP) across the stenosis. We proposed a non-invasive technique to derive ΔP using Phase-contrast (PC)-MRI in conjunction with the Navier-Stokes equations (ΔPMR). Excellent correlation was observed between derived ΔPMR and measure ΔP from a pressure transducer in a small caliber phantom model. A significant increase in ΔPMR was seen in the patient group vs. healthy controls. Preliminary results suggested that noninvasive quantification of ΔPMR in coronary arteries is feasible.

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