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Abstract #0358

Accuracy and optimal proton density fat fraction threshold of magnitude- and complex-based magnetic resonance imaging for diagnosis of hepatic steatosis in obese patients using histology as reference

Tydus Thai1, William Haufe1, Yesenia Covarrubias1, Alexandria Schlein1, Curtis N. Wiens2, Alan McMillan2, Nathan S. Artz2,3, Rashmi Agni4, Michael Peterson5, Luke Funk6, Guilherme M. Campos7, Jacob Greenberg6, Santiago Horgan8, Garth Jacobson8, Tanya Wolfson1, Jeffrey Schwimmer9, Scott Reeder2,10,11,12,13, and Claude Sirlin1

1Liver Imaging Group, Radiology, University of California-San Diego, San Diego, CA, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States, 4Pathology, University of Wisconsin-Madison, Madison, WI, United States, 5Western Washington Pathology and Multicare Health System, Tacoma, WA, United States, 6Surgery, University of Wisconsin-Madison, Madison, WI, United States, 7Surgery, Virginia Commonwealth University, Richmond, VA, United States, 8Surgery, University of California-San Diego, San Diego, CA, United States, 9Pediatrics, University of California-San Diego, San Diego, CA, United States, 10Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 11Biomedical Engineering, Madison, WI, United States, 12Medicine, Madison, WI, United States, 13Emergency Medicine, Madison, WI, United States

The purpose of this prospective cross-sectional study was to determine the accuracy of optimal MRI-M- and MRI-C-determined PDFF thresholds for diagnosis of hepatic steatosis using contemporaneous histology as reference in obese adults without previously known NAFLD. The excellent performance parameters of the Youden-index PDFF thresholds for MRI-M and MRI-C (5.3% and 7.7%, respectively) further support the use of these techniques for the quantitative and non-invasive diagnosis of HS. If validated by additional prospective studies, these PDFF thresholds could be used for diagnosing HS in obese adults non-invasively.

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