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Abstract #0361

Discrimination of Hepatic Inflammation and Fibrosis with Magnetic Resonance Elastography

Meng Yin1, Kevin J. Glaser1, Harmeet Malhi2, Amy Mauer2, Anuradha Krishnan2, Taofic Mounajjed3, Jason Bakeberg4, Christopher Ward4, Ruisi Wang2, Douglas Simonnetto2, Shennen Mao5, Jaime Glorioso5, Faysal Elgilani6, Vijay Shah2, Scott Nyberg6, Armando Manduca1, and Richard L. Ehman1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, 3Pathology, Mayo Clinic, Rochester, MN, United States, 4Nephrology and Hypertension Research, Mayo Clinic, Rochester, MN, United States, 5Surgery, Mayo Clinic, Rochester, MN, United States, 6Transplant Center, Mayo Clinic, Rochester, MN, United States

To investigate the utility of MRE-derived mechanical properties in discriminating hepatic inflammation and fibrosis in early-stage of chronic liver diseases, we performed multifrequency 3D MRE on five different in vivo animal models with chronic liver diseases. Liver stiffness and phase angle derived from complex shear modulus were selected for evaluation. Results demonstrated distinct and potentially characteristic changes in these mechanical properties with hepatic inflammation, fibrosis and increased portal pressure. The findings offer preliminary evidence of the potential to extend MRE to distinguish and independently assess necroinflammatory and fibrotic processes in the early phase of chronic liver diseases.

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