1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, People's Republic of, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, People's Republic of
We measured the apparent diffusion coefficients
(ADCs), as well as the relative concentrations of both intramyocellular lipid
(IMCL) and creatine in the rat muscle ischemia model. Comparing with the
metabolite concentration changes, the IMCL and creatine ADCs had largely increased
during muscle ischemia and the IMCL ADC increase was more drastic than
creatine. The IMCL ADC, measured by diffusion weighted MRS, had shown the
potential to probe the alterations in lipid droplet size and lipid metabolism
in skeletal muscles.
