Abstract #0398

Assessment of tumor perfusion, oxygenation, and metabolism using DCE, BOLD, and hyperpolarized 13C MRI in a mouse model of breast cancer

Erin B Adamson¹, Roberta M Strigel^1,2,3, David J Niles¹, Kai D Ludwig¹, Ben L Cox^1,4,5, Amy R Moser^2,6, and Sean B Fain^1,3,7

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States, ³Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁴Morgridge Institute for Research, Madison, WI, United States, ⁵Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI, United States, ⁶Human Oncology, University of Wisconsin-Madison, Madison, WI, United States, ⁷Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Hyperpolarized (HP) ¹³C MRSI, dynamic contrast-enhanced (DCE) MRI, and blood-oxygen-level dependent (BOLD) MRI have the potential to non-invasively characterize tumor metabolism, perfusion, and oxygenation, respectively, and aid in the development of individualized treatment plans for cancer patients. However, a regional comparison of these non-invasive techniques for probing the tumor microenvironment has not been explored. This work aims to test the feasibility of performing quantitative, spatial analysis and comparison of HP ¹³C MRSI and BOLD and DCE MRI in a murine breast cancer model.

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