Abstract #0418

A differential arterial blood volume response during Lower Body Negative Pressure measured using Pulsed Arterial Spin Labelling with multiple short inversion times

Joseph R Whittaker¹, Molly G Bright^1,2, Ian D Driver¹, Adele Babic^1,3, Martin Stuart¹, and Kevin Murphy¹

¹CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³Department of Anesthesia and Intensive Care Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom

A custom made MRI compatible lower body negative pressure (LBNP) chamber induced central hypovolemia in a group of healthy volunteers. Pulsed ASL data with multiple short inversion times was acquired during a baseline period and -40mmHg LBNP in order to estimate arterial cerebral blood volume changes related to cerebral autoregulation. We found a differential response, in which arterial blood volume changes during LBNP were dependent on vessel size. These data provide a useful first step for fully understand the complex vascular changes that occur in the brain to maintain perfusion during systemic physiological perturbations.

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