Renuka Sriram1, Bertram Koelsch1, Jeremy W Gordon1, Mark Van Criekinge1, Celine Baligand1, Robert A Bok1, Dan B Vigneron1, Kayvan R Keshari2, Peder E Larson1, Zhen Jane Wang1, and John Kurhanewicz1
1University of California, San Francisco, San Francisco, CA, United States, 2Memorial Sloan-Kettering Cancer Center, New York, NY, United States
This study demonstrated that diffusion weighted HP 13C MRI
can provide an estimate of the amount of extra- versus intracellular HP 13C
lactate based on its apparent diffusion coefficient (ADC). In metastatic
renal cell carcinoma, a large portion of the HP 13C lactate signal
arises from an extracellular lactate pool, based on reliable estimates of ADC in the same cell line in a the MR compatible bioreactor.
The juxtaposition of cells in bioreactor and the in vivo animal model is a powerful tool
for interpretation of the hyperpolarized ADC measurements. This unique
combination can be further extended to investigate the relationship between lactate
transport and tumor metastatic potential.