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Abstract #0446

Differential tumor perfusion in vivo on Arterial Spin Labeled MRI correlates with heterogeneity in the molecular phenotype of clear cell Renal Cell Carcinoma

Manoj Bhasin1, Rupal Bhatt2, Phillip M Robson3, Deepa Rajamani1, Sabina Signoretti4, David C Alsop3, and Ivan Pedrosa5

1Division of Interdisciplinary Medicine & Biotechnology, and Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States, 2Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 3Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 4Pathology, Brigam and Women's Hospital, Boston, MA, United States, 5Radiology, UT Southwestern Medical Center, Dallas, TX, United States

We used Arterial Spin Labeled (ASL) MRI to explore the association between heterogeneous in vivo perfusion in clear cell renal cell carcinoma (ccRCC) and the underlying genomic profile to identify key genes linked to tumor angiogenesis. Ephrin-A5 (EFNA5) expression correlated with ASL perfusion (R2 = 0.504, P value= .002) and exhibited highest significant differences between low and high perfusion (Fold Change = 2.88, P value < 0.02). Higher expression of EFNA5 is associated with poor 3 and 5 years survival (P = 0.0009). We propose MRI-based targeted tissue sampling to characterize the heterogeneous genetic alterations driving angiogenesis in ccRCC.

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