Shubhangi Agarwal1, Troy Kozlowski1, Rohini Vidya Shankar1, Landon J. Inge2, and Vikram D. Kodibagkar1
1SBHSE, Arizona State University, Tempe, AZ, United States, 2St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States
Solid tumors have hypoxic foci that be targeted using hypoxia
activated/targeting drugs. Utilizing quantitative MR oximetry techniques such
as the PISTOL (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels)
technique could allow for patient stratification for personalized therapy. This
study uses the PISTOL technique to evaluate how the hypoxia activated drug TPZ
(Tirapazamine) depends on and affects the oxygenation and edema fraction of
epidermoid carcinoma (A431) and non-small cell lung cancer (H1975).
Surprisingly, TPZ was more effective on the H1975 tumors than A431, in
spite of higher pre-treatment pO2 levels, potentially due to
perfusion-related differences in tumor drug delivery.