Added Value of Phase-Contrast MRI based Turbulent Kinetic Energy Quantification for the Assessment of Aortic Stenosis Severity
Alexander Gotschy1,2, Christian Binter1, Simon H Sündermann3, Michelle Frank2, Felix C Tanner2, Robert Manka2, and Sebastian Kozerke1
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, 3Division of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
Aortic stenosis (AS) is the most
prevalent valvular heart disease. Risk stratification and the decision for
valve replacement are mostly based on echocardiography and symptomaticity. This
work investigates the additional value of quantifying Turbulent Kinetic Energy (TKE) for the
assessment of AS severity beyond echocardiographic measures. TKE was confirmed to be significantly elevated in patients
with AS compared to controls. While TKE showed only weak correlation with the
echocardiographic Mean Pressure Gradient, TKE allowed to discriminate the
impact of bicuspid aortic valves and aortic dilatation on energy loss in AS patients;
effects which are not assessable by standard echocardiographic measures.
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