Meeting Banner
Abstract #0479

Deciphering the Functional Role of Locus Coeruleus-derived Norepinephrine using Chemogenetic fMRI and 18FDG-PET

Esteban Adrian Oyarzabal1,2, Manasmita Das3, Sung-Ho Adrian Lee4, Natale Sciolino2, Irina Evsyukova2, Patricia Jensen2, and Yen-Yu (Ian) Shih3

1Neurology, UNC-Chapel Hill, Carrboro, NC, United States, 2Laboratory of Neurobiology, NIEHS/NIH, Research Triangle Park, NC, United States, 3Neurology, UNC-Chapel Hill, Chapel Hill, NC, United States, 4UNC-Chapel Hill, Chapel Hill, NC, United States

This study examines how selective chemogenetic stimulation of noradrenergic neurons of the Locus Coeruleus (LC) in mice modulates cerebral metabolism and vascular tone. This was achieved by using a transgenic mouse line selectively expresses Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in the LC noradrenergic neurons. A multimodal imaging approach was used, with MRI being used to evaluate hemodynamic changes and PET being used to assess glucose metabolism.

This abstract and the presentation materials are available to members only; a login is required.

Join Here