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Abstract #0509

Deep brain nuclei T1 shortening after gadolinium in children: influence of radiation and chemotherapy

Sonja Kinner1,2, Tilman B Schubert1,3, Susan Rebsamen1, Richard Bruce1, Scott B Reeder1,4,5,6,7, and Howard A Rowley1

1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 2Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany, 3Clinic for Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland, 4Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 5Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 6Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 7Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

Recent studies report intrinsic T1 hyperintense signal in deep brain nuclei on MRI after multiple doses of gadolinium-based contrast agents in adults. We investigated whether similar T1 shortening was also found in children, and furthermore evaluated the influence of radiochemotherapy (RCTX) on its appearance. Signal increases were found in 2/60 children without RCTX and in 12/16 children with RCTX. Signal ratio changes were significantly different between the two groups and appeared with fewer doses in children with RCTX.

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